David Pfau: March 27th (at 5PM)

I'll be presenting on work in progress in collaboration with Bijan Pesaran's group (Yan Wong, Mariana Vigeral, David Putrino) and Josh Merel on building a high degree-of-freedom brain-machine interface.  I'll focus on the Bayesian paradigm for decoding, and two practical problems for pushing that paradigm beyond the commonly-used Kalman filtering approach: building better likelihoods, and building better priors.  The first amounts to fitting tuning curves for various neurons.  Other groups have shown a nonlinear dependence of firing rate on hand position in 3D space, here I will show some preliminary results on fitting tuning curves for large numbers of joint angles.  The second amounts to building better generative models of reach and grasp motions.  As a first step in that direction, I've looked at PCA and ICA for reducing the dimension of reach-and-grasp signals.

Kamiar Rahnama Rad: June 7th

Information rates and Optimal decoding in Large Populations

Many fundamental questions in theoretical neuroscience involve optimal decoding and the computation of Shannon information rates in populations of spiking neurons. In this paper, we apply methods from the asymptotic theory of statistical inference to obtain a clearer analytical understanding of these quantities. We find that for large neural populations carrying a finite total amount of information, the full spiking population response is asymptotically as informative as a single observation from a Gaussian process whose mean and covariance can be characterized explicitly in terms of network and single neuron properties. The Gaussian form of this asymptotic sufficient statistic allows us in certain cases to perform opti- mal Bayesian decoding by simple linear transformations, and to obtain closed-form expressions of the Shannon information carried by the network. One technical advantage of the theory is that it may be applied easily even to non-Poisson point process network models; for example, we find that under some conditions, neural populations with strong history-dependent (non-Poisson) effects carry exactly the same information as do simpler equivalent populations of non-interacting Poisson neurons with matched firing rates. We argue that our findings help to clarify some results from the recent literature on neural decoding and neuroprosthetic design.

Alex Ramirez : Feb. 8

Alex will be talking about: "Spike patterns in retinal ganglion cells required for decoding - a progress report."