Abstract: The amount of light absorbed and scattered by brain tissue is altered by neuronal activity. Imaging of “intrinsic optical signals” (ImIOS) is the technique of mapping these dynamic optical changes with high spatial and temporal resolution. ImIOS of the exposed brains of awake patients, performed during their neurosurgical treatment for intractable epilepsy, has unique advantages for studying certain aspects of the human brain. Better methods for the analysis and visualization of ImIOS data are motivated by at least two reasons. First, ImIOS can be used for investigating basic biological questions concerning the regulation of blood flow in the human brain during normal and epileptic activity. Second, optical imaging has the potential to be a practical clinical tool for localizing functional and epileptic brain regions in the operating room. My talk will focus on explaining the types of questions that can be investigated with optical imaging of the human brain, and illustrating the spatial and temporal features of these types of data that could benefit from better methods for their visualization and analysis.
A couple of relevant references: